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p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation

It is well established that p53 contacts DNA in a sequence-dependent manner in order to transactivate its myriad target genes. Yet little is known about how p53 interacts with its binding site/response element (RE) within such genes in vivo in the context of nucleosomal DNA. In this study we demonst...

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Bibliographic Details
Main Authors: Laptenko, Oleg, Beckerman, Rachel, Freulich, Ella, Prives, Carol
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127872/
https://ncbi.nlm.nih.gov/pubmed/21606339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105680108
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