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p53 binding to nucleosomes within the p21 promoter in vivo leads to nucleosome loss and transcriptional activation
It is well established that p53 contacts DNA in a sequence-dependent manner in order to transactivate its myriad target genes. Yet little is known about how p53 interacts with its binding site/response element (RE) within such genes in vivo in the context of nucleosomal DNA. In this study we demonst...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127872/ https://ncbi.nlm.nih.gov/pubmed/21606339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1105680108 |
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