लोड हो रहा है...
PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by phosphorylating cellular target proteins that activate DNA repair pathways and cell cycle checkpoints in order to maintain genomic integrity. Here we show that the oncogenic p53-...
में बचाया:
| मुख्य लेखकों: | , , |
|---|---|
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Cold Spring Harbor Laboratory Press
2005
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1132003/ https://ncbi.nlm.nih.gov/pubmed/15870257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1291305 |
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