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PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints
The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by phosphorylating cellular target proteins that activate DNA repair pathways and cell cycle checkpoints in order to maintain genomic integrity. Here we show that the oncogenic p53-...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1132003/ https://ncbi.nlm.nih.gov/pubmed/15870257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1291305 |
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