Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference

β-Arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of “scaffolded” pathways. To facilitate the discovery of novel adaptor...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ahn, Seungkirl, Nelson, Christopher D., Garrison, Tiffany Runyan, Miller, William E., Lefkowitz, Robert J.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2003
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149903/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12582207/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.262789099
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