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Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference
β-Arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of “scaffolded” pathways. To facilitate the discovery of novel adaptor...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC149903/ https://ncbi.nlm.nih.gov/pubmed/12582207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262789099 |
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