Desensitization, internalization, and signaling functions of β-arrestins demonstrated by RNA interference

β-Arrestins bind to activated G protein-coupled receptor kinase-phosphorylated receptors, which leads to their desensitization with respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list of “scaffolded” pathways. To facilitate the discovery of novel adaptor...

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Detalles Bibliográficos
Main Authors: Ahn, Seungkirl, Nelson, Christopher D., Garrison, Tiffany Runyan, Miller, William E., Lefkowitz, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC149903/
https://ncbi.nlm.nih.gov/pubmed/12582207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.262789099
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