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In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of...

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書誌詳細
出版年:J Virol
主要な著者: Trozzi, Caterina, Bartholomew, Linda, Ceccacci, Alessandra, Biasiol, Gabriella, Pacini, Laura, Altamura, Sergio, Narjes, Frank, Muraglia, Ester, Paonessa, Giacomo, Koch, Uwe, De Francesco, Raffaele, Steinkuhler, Christian, Migliaccio, Giovanni
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2003
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149541/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12610142/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.6.3669-3679.2003
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