In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of...

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Detalhes bibliográficos
Main Authors: Trozzi, Caterina, Bartholomew, Linda, Ceccacci, Alessandra, Biasiol, Gabriella, Pacini, Laura, Altamura, Sergio, Narjes, Frank, Muraglia, Ester, Paonessa, Giacomo, Koch, Uwe, De Francesco, Raffaele, Steinkuhler, Christian, Migliaccio, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC149541/
https://ncbi.nlm.nih.gov/pubmed/12610142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.6.3669-3679.2003
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