In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor

The hepatitis C virus (HCV) serine protease is necessary for viral replication and represents a valid target for developing new therapies for HCV infection. Potent and selective inhibitors of this enzyme have been identified and shown to inhibit HCV replication in tissue culture. The optimization of...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Trozzi, Caterina, Bartholomew, Linda, Ceccacci, Alessandra, Biasiol, Gabriella, Pacini, Laura, Altamura, Sergio, Narjes, Frank, Muraglia, Ester, Paonessa, Giacomo, Koch, Uwe, De Francesco, Raffaele, Steinkuhler, Christian, Migliaccio, Giovanni
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2003
Schlagworte:	Vaccines and Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC149541/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12610142/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.6.3669-3679.2003
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