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Development of Cyclic γ-MSH Analogues with Selective hMC3R Agonist and hMC3R/hMC5R Antagonist Activities
A series of cyclic lactam analogues of γ-MSH (H-Tyr(1)-Val(2)-Met(3)-Gly(4)-His(5)-Phe(6)-Arg(7)-Trp(8)-Asp(9)-Arg(10)-Phe(11)-Gly(12)-OH) with a bulky hydrophobic residue in the direct proximity to the pharmacophore (Xaa-d-Phe/d-Nal(2′)-Arg-Trp) were designed and synthesized by solid-phase methods....
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1484467/ https://ncbi.nlm.nih.gov/pubmed/16539382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0510326 |
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