Development of Cyclic γ-MSH Analogues with Selective hMC3R Agonist and hMC3R/hMC5R Antagonist Activities

A series of cyclic lactam analogues of γ-MSH (H-Tyr(1)-Val(2)-Met(3)-Gly(4)-His(5)-Phe(6)-Arg(7)-Trp(8)-Asp(9)-Arg(10)-Phe(11)-Gly(12)-OH) with a bulky hydrophobic residue in the direct proximity to the pharmacophore (Xaa-d-Phe/d-Nal(2′)-Arg-Trp) were designed and synthesized by solid-phase methods....

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Detalhes bibliográficos
Main Authors: Mayorov, Alexander V., Cai, Minying, Chandler, Kevin B., Petrov, Ravil R., Van Scoy, April R., Yu, Zerui, Tanaka, Dustin K., Trivedi, Dev, Hruby, Victor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1484467/
https://ncbi.nlm.nih.gov/pubmed/16539382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm0510326
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