Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist

[Image: see text] To address the need for highly potent, metabolically stable, and selective agonists, antagonists, and inverse agonists at the melanocortin receptor subtypes, conformationally constrained indolo- and benzazepinone residues were inserted into the α-MSH pharmacophore, His(6)-Phe(7)-Ar...

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Publicado en:ACS Med Chem Lett
Autores principales: Van der Poorten, Olivier, Fehér, Krisztina, Buysse, Koen, Feytens, Debby, Zoi, Ioanna, Schwartz, Steven D., Martins, José C., Tourwé, Dirk, Cai, Minying, Hruby, Victor J., Ballet, Steven
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329577/
https://ncbi.nlm.nih.gov/pubmed/25699148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500436s
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