Azepinone-Containing Tetrapeptide Analogues of Melanotropin Lead to Selective hMC4R Agonists and hMC5R Antagonist

[Image: see text] To address the need for highly potent, metabolically stable, and selective agonists, antagonists, and inverse agonists at the melanocortin receptor subtypes, conformationally constrained indolo- and benzazepinone residues were inserted into the α-MSH pharmacophore, His(6)-Phe(7)-Ar...

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Publicat a:ACS Med Chem Lett
Autors principals: Van der Poorten, Olivier, Fehér, Krisztina, Buysse, Koen, Feytens, Debby, Zoi, Ioanna, Schwartz, Steven D., Martins, José C., Tourwé, Dirk, Cai, Minying, Hruby, Victor J., Ballet, Steven
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4329577/
https://ncbi.nlm.nih.gov/pubmed/25699148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500436s
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