Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo

BACKGROUND: 2,5-Dimethyl-celecoxib (DMC) is a close structural analog of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib (Celebrex(®)) that lacks COX-2-inhibitory function. However, despite its inability to block COX-2 activity, DMC is able to potently mimic the anti-tumor effects of cele...

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Detalhes bibliográficos
Main Authors: Pyrko, Peter, Soriano, Nathaniel, Kardosh, Adel, Liu, Yen-Ting, Uddin, Jasim, Petasis, Nicos A, Hofman, Florence M, Chen, Ching-Shih, Chen, Thomas C, Schönthal, Axel H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479836/
https://ncbi.nlm.nih.gov/pubmed/16707021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-5-19
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