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Stereocontrolled Total Synthesis of the Potent Anti-inflammatory and Pro-resolving Lipid Mediator Resolvin D3 and its Aspirin-Triggered 17R-Epimer

[Image: see text] The first total synthesis of stereochemically pure resolvin D3 and aspirin-triggered resolvin D3 is reported. These enzymatic metabolites of docosahexaenoic acid (DHA) have potent anti-inflammatory and pro-resolving actions. The convergent synthetic strategy is based on enantiomeri...

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Autori principali: Winkler, Jeremy W., Uddin, Jasim, Serhan, Charles N., Petasis, Nicos A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696528/
https://ncbi.nlm.nih.gov/pubmed/23510485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol400484u
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