Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy

Por Chen, Thomas C, Fonseca, Clovis O Da, Schönthal, Axel H
Publicado no Am J Cancer Res (2015)

Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases

Por Chen, Thomas C., Da Fonseca, Clovis O., Schönthal, Axel H.
Publicado no Int J Mol Sci (2016)

NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion

Por Marín-Ramos, Nagore I., Hofman, Florence M., Chen, Thomas C.
Publicado no Oncoscience (2018)

Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development

Por Chen, Thomas C., da Fonseca, Clovis O., Schönthal, Axel H.
Publicado no Int J Mol Sci (2018)

DDRE-06. REGULATION OF TUMOR MICROENVIRONMENT VIA ENDOTHELIAL-TO-MESENCHYMAL TRANSITION BLOCKADE IN GLIOBLASTOMA-ASSOCIATED BRAIN ENDOTHELIAL CELLS

Por Marin’ Ramos, Nagore I, Jhaveri, Niyati, Thein, Thu Zan, Chen, Thomas C
Publicado no Neurooncol Adv (2021)

NEO212: A NOVEL TEMOZOLOMIDE-PERILLYL ALCOHOL CONJUGATE EXHIBITS SUPERIOR ACTIVITY AGAINST TEMOZOLOMIDE RESISTANT GLIOMAS AND INTRACRANIAL TRIPLE NEGATIVE BREAST CANCER METASTASIS

Por Chen, Thomas C., Schonthal, Axel H., Hofman, Florence M., Wang, Weijun, Cho, Heeyon
Publicado em 2014

Distribution of cancer stem cells in two human brain gliomas

Por Peng, Lilei, Fu, Jie, Wang, Weijun, Hofman, Florence M., Chen, Thomas C., Chen, Ligang
Publicado no Oncol Lett (2019)

Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer

Por Song, Xingguo, Xie, Li, Wang, Xingwu, Zeng, Qian, Chen, Thomas C., Wang, Weijun, Song, Xianrang
Publicado no Sci Rep (2016)

Temozolomide–perillyl alcohol conjugate downregulates O(6)-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer

Por Song, Xingguo, Xie, Li, Chang, Minghui, Geng, Xinran, Wang, Xingwu, Chen, Thomas C., Song, Xianrang
Publicado no Cell Death Dis (2018)

Increased Survivin Expression Confers Chemoresistance to Tumor-Associated Endothelial Cells

Por Virrey, Jenilyn J., Guan, Shengxi, Li, Wei, Schönthal, Axel H., Chen, Thomas C., Hofman, Florence M.
Publicado em 2008

“A-Mode Ultrasound Guidance for Pedicle Screw Advancement in Ovine Vertebral Bodies” Manuscript: Technical Report

Por Raphael, David T., Chang, Jin Ho, Zhang, Yao Ping, Kudija, David, Chen, Thomas C., Shung, K. Kirk
Publicado em 2010

Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treat...

Por Chen, Thomas C., Chan, Nymph, Minea, Radu O., Hartman, Hannah, Hofman, Florence M., Schönthal, Axel H.
Publicado no Cancers (Basel) (2018)

A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice

Por Swenson, Steve, Minea, Radu O., Tuan, Cao Duc, Thein, Thu-Zan, Chen, Thomas C., Markland, Francis S.
Publicado no Molecules (2018)

Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation

Por Chang, Minghui, Song, Xingguo, Geng, Xinran, Wang, Xingwu, Wang, Weijun, Chen, Thomas C., Xie, Li, Song, Xianrang
Publicado no J Exp Clin Cancer Res (2018)

ATPS-07 NEO214, ROLIPRAM CONJUGATED TO PERILLYL ALCOHOL, IS A NOVEL DRUG CYTOTOXIC FOR GLIOMAS BY TARGETING THE DEATH RECEPTOR MEDIATED TRAIL PATHWAY

Por Cho, Hee-Yeon, Wang, Weijun, Huang, Mickey, Santiago, Shayane, Schönthal, Axel H., Hofman, Florence M., Chen, Thomas C.
Publicado no Neuro Oncol (2015)

Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram

Por Chen, Thomas C., Chan, Nymph, Labib, Shirin, Yu, Jiali, Cho, Hee-Yeon, Hofman, Florence M., Schönthal, Axel H.
Publicado no Int J Mol Sci (2018)

NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer

Por Song, Xingguo, Liu, Lisheng, Chang, Minghui, Geng, Xinran, Wang, Xingwu, Wang, Weijun, Chen, Thomas C., Xie, Li, Song, Xianrang
Publicado no J Exp Clin Cancer Res (2019)

Fasting Enhances the Response of Glioma to Chemo- and Radiotherapy

Por Safdie, Fernando, Brandhorst, Sebastian, Wei, Min, Wang, Weijun, Lee, Changhan, Hwang, Saewon, Conti, Peter S., Chen, Thomas C., Longo, Valter D.
Publicado em 2012

Argonaute‐2 Promotes miR‐18a Entry in Human Brain Endothelial Cells

Por Ferreira, Raquel, Santos, Tiago, Amar, Arun, Gong, Alex, Chen, Thomas C., Tahara, Stanley M., Giannotta, Steven L., Hofman, Florence M.
Publicado no J Am Heart Assoc (2014)

Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties

Por Rosa, Alexandra I., Grade, Sofia, Santos, Sofia D., Bernardino, Liliana, Chen, Thomas C., Relvas, João, Hofman, Florence M., Agasse, Fabienne
Publicado no Front Cell Neurosci (2016)