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COX-2 inhibition is neither necessary nor sufficient for celecoxib to suppress tumor cell proliferation and focus formation in vitro

BACKGROUND: An increasing number of reports is challenging the notion that the antitumor potential of the selective COX-2 inhibitor celecoxib (Celebrex(®)) is mediated primarily via the inhibition of COX-2. We have investigated this issue by applying two different analogs of celecoxib that different...

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Detalhes bibliográficos
Main Authors: Chuang, Huan-Ching, Kardosh, Adel, Gaffney, Kevin J, Petasis, Nicos A, Schönthal, Axel H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396175/
https://ncbi.nlm.nih.gov/pubmed/18485224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-7-38
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