Tumor Regression and Autoimmunity in Patients Treated With Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Interleukin 2: A Phase I/II Study

BACKGROUND: Cytotoxic T lymphocyte–associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The pos...

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Main Authors: Maker, Ajay V., Phan, Giao Q., Attia, Peter, Yang, James C., Sherry, Richard M., Topalian, Suzanne L., Kammula, Udai S., Royal, Richard E., Haworth, Leah R., Levy, Catherine, Kleiner, David, Mavroukakis, Sharon A., Yellin, Michael, Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1473970/
https://ncbi.nlm.nih.gov/pubmed/16283570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/ASO.2005.03.536
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