Cytotoxic T-Lymphocyte–Associated Antigen-4 Blockage Can Induce Autoimmune Hypophysitis in Patients With Metastatic Melanoma and Renal Cancer

Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) is an immunoregulatory molecule expressed by activated T cells and resting CD4(+)CD25(+) T cells. In patients with advanced melanoma, our group reported that administration of anti-CTLA-4 antibody mediated objective cancer regression in 13% of pat...

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Detalhes bibliográficos
Main Authors: Blansfield, Joseph A., Beck, Kimberly E., Tran, Khoi, Yang, James C., Hughes, Marybeth S., Kammula, Udai S., Royal, Richard E., Topalian, Suzanne L., Haworth, Leah R., Levy, Catherine, Rosenberg, Steven A., Sherry, Richard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154350/
https://ncbi.nlm.nih.gov/pubmed/16224277
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