Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

The inhibitory receptor CTLA4 has a key role in peripheral tolerance of T cells for both normal and tumor-associated antigens. Murine experiments suggested that blockade of CTLA4 might have antitumor activity and a clinical experience with the blocking antibody ipilimumab in patients with metastatic...

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Главные авторы: Yang, James C., Hughes, Marybeth, Kammula, Udai, Royal, Richard, Sherry, Richard M., Topalian, Suzanne L., Suri, Kimberly B., Levy, Catherine, Allen, Tamika, Mavroukakis, Sharon, Lowy, Israel, White, Donald E., Rosenberg, Steven A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2007
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134980/
https://ncbi.nlm.nih.gov/pubmed/18049334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e318156e47e
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