Ipilimumab (Anti-CTLA4 Antibody) Causes Regression of Metastatic Renal Cell Cancer Associated With Enteritis and Hypophysitis

The inhibitory receptor CTLA4 has a key role in peripheral tolerance of T cells for both normal and tumor-associated antigens. Murine experiments suggested that blockade of CTLA4 might have antitumor activity and a clinical experience with the blocking antibody ipilimumab in patients with metastatic...

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Detalhes bibliográficos
Main Authors: Yang, James C., Hughes, Marybeth, Kammula, Udai, Royal, Richard, Sherry, Richard M., Topalian, Suzanne L., Suri, Kimberly B., Levy, Catherine, Allen, Tamika, Mavroukakis, Sharon, Lowy, Israel, White, Donald E., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134980/
https://ncbi.nlm.nih.gov/pubmed/18049334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e318156e47e
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