Tumor Regression and Autoimmunity in Patients Treated With Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Interleukin 2: A Phase I/II Study

BACKGROUND: Cytotoxic T lymphocyte–associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The pos...

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Bibliografiske detaljer
Main Authors: Maker, Ajay V., Phan, Giao Q., Attia, Peter, Yang, James C., Sherry, Richard M., Topalian, Suzanne L., Kammula, Udai S., Royal, Richard E., Haworth, Leah R., Levy, Catherine, Kleiner, David, Mavroukakis, Sharon A., Yellin, Michael, Rosenberg, Steven A.
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1473970/
https://ncbi.nlm.nih.gov/pubmed/16283570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/ASO.2005.03.536
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