Tumor Regression and Autoimmunity in Patients Treated With Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Interleukin 2: A Phase I/II Study

BACKGROUND: Cytotoxic T lymphocyte–associated antigen (CTLA)-4 can inhibit T-cell responses and is involved in tolerance against self antigens. We previously reported autoimmune manifestations and objective cancer regressions in patients with metastatic melanoma treated with CTLA-4 blockade. The pos...

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Détails bibliographiques
Auteurs principaux: Maker, Ajay V., Phan, Giao Q., Attia, Peter, Yang, James C., Sherry, Richard M., Topalian, Suzanne L., Kammula, Udai S., Royal, Richard E., Haworth, Leah R., Levy, Catherine, Kleiner, David, Mavroukakis, Sharon A., Yellin, Michael, Rosenberg, Steven A.
Format: Artigo
Langue:Inglês
Publié: 2005
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1473970/
https://ncbi.nlm.nih.gov/pubmed/16283570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/ASO.2005.03.536
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