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TAR RNA decoys inhibit tat-activated HIV-1 transcription after preinitiation complex formation.

The ability of the HIV-1 Tat protein to trans -activate HIV-1 transcription in vitro is specifically inhibited by a circular TAR RNA decoy. This inhibition is not overcome by adding an excess of Tat to the reaction but is partially overcome by adding Tat in combination with nuclear extract, suggesti...

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Udgivet i:Nucleic Acids Res
Principais autores: Bohjanen, P R, Liu, Y, Garcia-Blanco, M A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147068/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9358155/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.22.4481
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