Phosphorylation of HIV Tat by PKR increases interaction with TAR RNA and enhances transcription
<p>Abstract</p> <p>Background</p> <p>The interferon (IFN)-induced, dsRNA-dependent serine/threonine protein kinase, PKR, plays a key regulatory role in the IFN-mediated anti-viral response by blocking translation in the infected cell by phosphorylating the alpha subunit of elongation factor 2 (eIF2)...
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| Principais autores: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2005-02-01
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| Serier: | Virology Journal |
| Online adgang: | http://www.virologyj.com/content/2/1/17 |
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