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Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique
Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the ‘dynamic action potential clamp’ (dAPC) technique to effectively replace the native sodium current (I(Na)) of the Priebe–Beuckelmann human ventricular cell model with wild-type (WT) or mut...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Blackwell Science Inc
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1464302/ https://ncbi.nlm.nih.gov/pubmed/16254012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.096578 |
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