Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the ‘dynamic action potential clamp’ (dAPC) technique to effectively replace the native sodium current (I(Na)) of the Priebe–Beuckelmann human ventricular cell model with wild-type (WT) or mut...

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Autores principales: Berecki, Géza, Zegers, Jan G, Bhuiyan, Zahurul A, Verkerk, Arie O, Wilders, Ronald, van Ginneken, Antoni CG
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 2006
Materias:
Cellular
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464302/
https://ncbi.nlm.nih.gov/pubmed/16254012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.096578
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