Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the ‘dynamic action potential clamp’ (dAPC) technique to effectively replace the native sodium current (I(Na)) of the Priebe–Beuckelmann human ventricular cell model with wild-type (WT) or mut...

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Detaylı Bibliyografya
Asıl Yazarlar: Berecki, Géza, Zegers, Jan G, Bhuiyan, Zahurul A, Verkerk, Arie O, Wilders, Ronald, van Ginneken, Antoni CG
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Science Inc 2006
Konular:
Cellular
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464302/
https://ncbi.nlm.nih.gov/pubmed/16254012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.096578
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