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Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique

Long-QT3 syndrome (LQT3) is linked to cardiac sodium channel gene (SCN5A) mutations. In this study, we used the ‘dynamic action potential clamp’ (dAPC) technique to effectively replace the native sodium current (I(Na)) of the Priebe–Beuckelmann human ventricular cell model with wild-type (WT) or mut...

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Detalhes bibliográficos
Main Authors: Berecki, Géza, Zegers, Jan G, Bhuiyan, Zahurul A, Verkerk, Arie O, Wilders, Ronald, van Ginneken, Antoni CG
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1464302/
https://ncbi.nlm.nih.gov/pubmed/16254012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2005.096578
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