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Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice
The genes of the vertebrate β-globin locus undergo a switch in expression during erythroid development whereby embryonic/fetal genes of the cluster are sequentially silenced and adult genes are activated. We describe here a role for DNA methylation and MBD2 in the silencing of the human fetal γ-glob...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1458932/ https://ncbi.nlm.nih.gov/pubmed/16608912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509322103 |
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