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Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be the same: an increase in fetal hemoglobin. A GATA-1-FOG-1-Mi2 repressor comple...

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Detalhes bibliográficos
Main Authors: Costa, Flávia C., Fedosyuk, Halyna, Chazelle, Allen M., Neades, Renee Y., Peterson, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527334/
https://ncbi.nlm.nih.gov/pubmed/23284307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003155
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