Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be the same: an increase in fetal hemoglobin. A GATA-1-FOG-1-Mi2 repressor comple...

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Bibliographic Details
Main Authors: Costa, Flávia C., Fedosyuk, Halyna, Chazelle, Allen M., Neades, Renee Y., Peterson, Kenneth R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3527334/
https://ncbi.nlm.nih.gov/pubmed/23284307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003155
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