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Deletion of the human β-globin LCR 5’HS4 or 5’HS1 differentially affects β-like globin gene expression in β-YAC transgenic mice
A 213 Kb human β-globin locus yeast artificial chromosome (β-YAC) was modified by homologous recombination to delete 2.9 Kb of cross-species conserved sequence similarity encompassing the LCR 5’ hypersensitive site (HS) 4 (Δ5’HS4 β-YAC). In three transgenic mouse lines, completion of the γ- to β-glo...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1934938/ https://ncbi.nlm.nih.gov/pubmed/17433733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2007.02.006 |
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