Synergistic and Additive Properties of the Beta-Globin Locus Control Region (LCR) Revealed by 5′HS3 Deletion Mutations: Implication for LCR Chromatin Architecture

Deletion of the 234-bp core element of the DNase I hypersensitive site 3 (5′HS3) of the locus control region (LCR) in the context of a human beta-globin locus yeast artificial chromosome (β-YAC) results in profound effects on globin gene expression in transgenic mice. In contrast, deletion of a 2.3-...

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Bibliographische Detailangaben
Hauptverfasser: Fang, Xiangdong, Sun, Jin, Xiang, Ping, Yu, Man, Navas, Patrick A., Peterson, Kenneth R., Stamatoyannopoulos, George, Li, Qiliang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190234/
https://ncbi.nlm.nih.gov/pubmed/16055715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.16.7033-7041.2005
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