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Genome Architecture of the Human β-Globin Locus Affects Developmental Regulation of Gene Expression

To test the role of gene order in globin gene expression, mutant human β-globin locus yeast artificial chromosome constructs were used, each having one additional globin gene encoding a “marked” transcript (ɛ(m), γ(m), or β(m)) integrated at different locations within the locus. When a β(m)-globin g...

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Detalhes bibliográficos
Main Authors: Harju, Susanna, Navas, Patrick A., Stamatoyannopoulos, George, Peterson, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265765/
https://ncbi.nlm.nih.gov/pubmed/16199858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.20.8765-8778.2005
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