Methylation of the minimal promoter of an embryonic globin gene silences transcription in primary erythroid cells

Methylation of cytosines in the dinucleotide CpG has been shown to suppress transcription of a number of tissue-specific genes, yet the precise mechanism is not fully understood. The vertebrate globin genes were among the first examples in which an inverse correlation was shown between CpG methylati...

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Bibliografiska uppgifter
Huvudupphovsmän: Singal, Rakesh, Ferris, Richard, Little, Jane A., Wang, Shu Zhen, Ginder, Gordon D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The National Academy of Sciences of the USA 1997
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC28373/
https://ncbi.nlm.nih.gov/pubmed/9391093
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