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Methyl binding domain protein 2 mediates γ-globin gene silencing in adult human βYAC transgenic mice

The genes of the vertebrate β-globin locus undergo a switch in expression during erythroid development whereby embryonic/fetal genes of the cluster are sequentially silenced and adult genes are activated. We describe here a role for DNA methylation and MBD2 in the silencing of the human fetal γ-glob...

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Detaylı Bibliyografya
Asıl Yazarlar: Rupon, Jeremy W., Wang, Shou Zhen, Gaensler, Karin, Lloyd, Joyce, Ginder, Gordon D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2006
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1458932/
https://ncbi.nlm.nih.gov/pubmed/16608912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509322103
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