Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70

Granzyme A (GzmA) induces caspase-independent cell death with morphological features of apoptosis. Here, we show that GzmA at nanomolar concentrations cleaves Ku70, a key double-strand break repair (DSBR) protein, in target cells. Ku70 is cut after Arg(301), disrupting Ku complex binding to DNA. Cle...

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Pengcheng, Zhang, Dong, Chowdhury, Dipanjan, Martinvalet, Denis, Keefe, Dennis, Shi, Lianfa, Lieberman, Judy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Scientific Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456912/
https://ncbi.nlm.nih.gov/pubmed/16440001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400622
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