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Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
Heterodimers of the 70 and 80 kDa Ku autoantigens (Ku70 and Ku80) activate the DNA-dependent protein kinase (DNA-PK). Mutations in any of the three subunits of this protein kinase (Ku70, Ku80 and DNA-PKcs) lead to sensitivity to ionizing radiation (IR) and to DNA double-strand breaks, and V(D)J reco...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
1997
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1170290/ https://ncbi.nlm.nih.gov/pubmed/9362500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.22.6874 |
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