VCP/p97 extracts sterically trapped Ku70/80 rings from DNA in double strand break repair

During DNA double strand break (DSB) repair, the ring-shaped Ku70/80 complex becomes trapped on DNA and needs to be actively extracted, but it has remained unclear what provides the required energy. By means of reconstitution of DSB repair on beads, we demonstrate here that DNA-locked Ku rings are r...

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Publicado en:Mol Cell
Autores principales: van den Boom, Johannes, Wolf, Markus, Weimann, Lena, Schulze, Nina, Li, Fanghua, Kaschani, Farnusch, Riemer, Anne, Zierhut, Christian, Kaiser, Markus, Iliakis, George, Funabiki, Hironori, Meyer, Hemmo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161236/
https://ncbi.nlm.nih.gov/pubmed/27716483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.037
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