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Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70
Granzyme A (GzmA) induces caspase-independent cell death with morphological features of apoptosis. Here, we show that GzmA at nanomolar concentrations cleaves Ku70, a key double-strand break repair (DSBR) protein, in target cells. Ku70 is cut after Arg(301), disrupting Ku complex binding to DNA. Cle...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1456912/ https://ncbi.nlm.nih.gov/pubmed/16440001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400622 |
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