Hypoxia modulates early events in T cell receptor-mediated activation in human T lymphocytes via Kv1.3 channels

T lymphocytes are exposed to hypoxia during their development and when they migrate to hypoxic pathological sites. Although it has been shown that hypoxia inhibits Kv1.3 channels and proliferation in human T cells, the mechanisms by which hypoxia regulates T cell activation are not fully understood....

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Bibliographic Details
Main Authors: Robbins, Jennifer R, Lee, Susan Molleran, Filipovich, Alexandra H, Szigligeti, Peter, Neumeier, Lisa, Petrovic, Milan, Conforti, Laura
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Cell Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456048/
https://ncbi.nlm.nih.gov/pubmed/15677684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.081893
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