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Disruption of Kv1.3 Channel Forward Vesicular Trafficking by Hypoxia in Human T Lymphocytes

Hypoxia in solid tumors contributes to decreased immunosurveillance via down-regulation of Kv1.3 channels in T lymphocytes and associated T cell function inhibition. However, the mechanisms responsible for Kv1.3 down-regulation are not understood. We hypothesized that chronic hypoxia reduces Kv1.3 s...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Chimote, Ameet A., Kuras, Zerrin, Conforti, Laura
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265885/
https://ncbi.nlm.nih.gov/pubmed/22134923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.274209
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