Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus

Lupus nephritis (LN) is an autoimmune disease with substantial morbidity/mortality and limited efficacy of available therapies. Memory T (Tm) lymphocytes infiltrate LN kidneys, contributing to organ damage. Analysis of LN, diabetic nephropathy, and healthy donor kidney biopsies revealed high infiltr...

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Publicat a:Sci Adv
Autors principals: Khodoun, Marat, Chimote, Ameet A., Ilyas, Farhan Z., Duncan, Heather J., Moncrieffe, Halima, Kant, K. Shashi, Conforti, Laura
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673800/
https://ncbi.nlm.nih.gov/pubmed/33208373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd1471
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