Kv1.3 channels mark functionally competent CD8(+) tumor infiltrating lymphocytes in head and neck cancer

Tumor infiltrating lymphocytes (TILs) are potent mediators of an anti-tumor response. However, their function is attenuated in solid tumors. CD8(+) T cell effector functions such as cytokine and granzyme production depend on cytoplasmic Ca(2+), which is controlled by ion channels. In particular, Kv1...

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Vydáno v:Cancer Res
Hlavní autoři: Chimote, Ameet A., Hajdu, Peter, Sfyris, Alexandros M., Gleich, Brittany N., Wise-Draper, Trisha, Casper, Keith A., Conforti, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215046/
https://ncbi.nlm.nih.gov/pubmed/27815390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2372
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