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Kv1.3 channels mark functionally competent CD8(+) tumor infiltrating lymphocytes in head and neck cancer
Tumor infiltrating lymphocytes (TILs) are potent mediators of an anti-tumor response. However, their function is attenuated in solid tumors. CD8(+) T cell effector functions such as cytokine and granzyme production depend on cytoplasmic Ca(2+), which is controlled by ion channels. In particular, Kv1...
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| Publicado no: | Cancer Res |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5215046/ https://ncbi.nlm.nih.gov/pubmed/27815390 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2372 |
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