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Targeted knockdown of the adenosine A(2A) receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells

In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8(+) T cell functions including chemotaxis and tumor infiltration. Adenosine functions through binding to the adenosine A(2...

詳細記述

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書誌詳細
出版年:Mol Ther Methods Clin Dev
主要な著者: Newton, Hannah S., Chimote, Ameet A., Arnold, Michael J., Wise-Draper, Trisha M., Conforti, Laura
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Gene & Cell Therapy 2021
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005736/
https://ncbi.nlm.nih.gov/pubmed/33816646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.001
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