Targeted knockdown of the adenosine A(2A) receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells

In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8(+) T cell functions including chemotaxis and tumor infiltration. Adenosine functions through binding to the adenosine A(2...

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Vydáno v:Mol Ther Methods Clin Dev
Hlavní autoři: Newton, Hannah S., Chimote, Ameet A., Arnold, Michael J., Wise-Draper, Trisha M., Conforti, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Gene & Cell Therapy 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8005736/
https://ncbi.nlm.nih.gov/pubmed/33816646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.001
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