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Targeted knockdown of the adenosine A(2A) receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8(+) T cell functions including chemotaxis and tumor infiltration. Adenosine functions through binding to the adenosine A(2...
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| 出版年: | Mol Ther Methods Clin Dev |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Gene & Cell Therapy
2021
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8005736/ https://ncbi.nlm.nih.gov/pubmed/33816646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.001 |
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