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Targeted knockdown of the adenosine A(2A) receptor by lipid NPs rescues the chemotaxis of head and neck cancer memory T cells
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8(+) T cell functions including chemotaxis and tumor infiltration. Adenosine functions through binding to the adenosine A(2...
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| Publicado no: | Mol Ther Methods Clin Dev |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8005736/ https://ncbi.nlm.nih.gov/pubmed/33816646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.03.001 |
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