Signalling during hypoxia in human T lymphocytes – critical role of the src protein tyrosine kinase p56Lck in the O(2) sensitivity of Kv1.3 channels

T lymphocytes encounter hypoxia when they migrate to pathological sites such as tumours and wounds. The inability of T cells to provide an efficient defence at these sites can in part be explained by the hypoxic environment. Kv1.3 channels, important components of the T cell activation process are i...

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Hlavní autoři: Szigligeti, Peter, Neumeier, Lisa, Duke, Eugene, Chougnet, Claire, Takimoto, Koichi, Lee, Susan Molleran, Filipovich, Alexandra H, Conforti, Laura
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2006
Témata:
Cellular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1779731/
https://ncbi.nlm.nih.gov/pubmed/16600997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.109967
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