Compound-specific Na(+) channel pore conformational changes induced by local anaesthetics

Upon prolonged depolarizations, voltage-dependent Na(+) channels open and subsequently inactivate, occupying fast and slow inactivated conformational states. Like C-type inactivation in K(+) channels, slow inactivation is thought to be accompanied by rearrangement of the channel pore. Cysteine-label...

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Bibliographic Details
Main Authors: Fukuda, Koji, Nakajima, Tadashi, Viswanathan, Prakash C, Balser, Jeffrey R
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2005
Subjects:
Molecular and Genomic Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456037/
https://ncbi.nlm.nih.gov/pubmed/15677685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2004.081646
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