A conserved ring of charge in mammalian Na(+) channels: a molecular regulator of the outer pore conformation during slow inactivation

The molecular mechanisms underlying slow inactivation in sodium channels are elusive. Our results suggest that EEDD, a highly conserved ring of charge in the external vestibule of mammalian voltage-gated sodium channels, undermines slow inactivation. By employing site-directed mutagenesis, we found...

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Detalles Bibliográficos
Main Authors: Xiong, Wei, Farukhi, Yousaf Z, Tian, Yanli, DiSilvestre, Deborah, Li, Ronald A, Tomaselli, Gordon F
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2006
Assuntos:
Molecular and Genomic
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1890405/
https://ncbi.nlm.nih.gov/pubmed/16873407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.115105
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