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A conserved ring of charge in mammalian Na(+) channels: a molecular regulator of the outer pore conformation during slow inactivation
The molecular mechanisms underlying slow inactivation in sodium channels are elusive. Our results suggest that EEDD, a highly conserved ring of charge in the external vestibule of mammalian voltage-gated sodium channels, undermines slow inactivation. By employing site-directed mutagenesis, we found...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1890405/ https://ncbi.nlm.nih.gov/pubmed/16873407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2006.115105 |
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