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Molecular Motions of the Outer Ring of Charge of the Sodium Channel: Do They Couple to Slow Inactivation?

In contrast to fast inactivation, the molecular basis of sodium (Na) channel slow inactivation is poorly understood. It has been suggested that structural rearrangements in the outer pore mediate slow inactivation of Na channels similar to C-type inactivation in potassium (K) channels. We probed the...

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Detalhes bibliográficos
Main Authors: Xiong, Wei, Li, Ronald A., Tian, Yanli, Tomaselli, Gordon F.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234489/
https://ncbi.nlm.nih.gov/pubmed/12913092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308881
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