A Structural Rearrangement in the Sodium Channel Pore Linked to Slow Inactivation and Use Dependence

Voltage-gated sodium (Na(+)) channels are a fundamental target for modulating excitability in neuronal and muscle cells. When depolarized, Na(+) channels may gradually enter long-lived, slow-inactivated conformational states, causing a cumulative loss of function. Although the structural motifs that...

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Main Authors: Ong, Boon-Hooi, Tomaselli, Gordon F., Balser, Jeffrey R.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2000
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2229478/
https://ncbi.nlm.nih.gov/pubmed/11055994
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