The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation

Slow inactivation in voltage-gated sodium channels (Na(V)s) directly regulates the excitability of neurons, cardiac myocytes, and skeletal muscles. Although Na(V) slow inactivation appears to be conserved across phylogenies—from bacteria to humans—the structural basis for this mechanism remains uncl...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Chatterjee, Soumili, Vyas, Rajan, Chalamalasetti, Sreevatsa V., Sahu, Indra D., Clatot, Jérôme, Wan, Xiaoping, Lorigan, Gary A., Deschênes, Isabelle, Chakrapani, Sudha
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122925/
https://ncbi.nlm.nih.gov/pubmed/30082431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812118
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